Intelence (etravirine) Patient Assistance Program
Don’t let the high cost of brand HIV NNRTI disrupt your treatment-experienced HIV therapy. We help eligible patients access Intelence (etravirine tablets) for as little as $69.95 per month through the manufacturer’s Patient Assistance Program.
- Clear & Transparent Pricing
- Paperwork & Doctor-Coordination
- Comprehensive Support: From Application to Entire Journey
- Annual Re-certification And Refills Management
- Medicare Part D Patients Accepted
Key Takeaways:
- Intelence (etravirine) is FDA-approved in combination with other antiretrovirals for treatment of HIV-1 infection in treatment-experienced adult and pediatric patients (2 years and older) with evidence of viral replication and HIV-1 strains resistant to a non-nucleoside reverse transcriptase inhibitor (NNRTI) and other antiretrovirals. Second-generation NNRTI — retains activity against many NNRTI-resistant HIV strains.
- Without assistance, Intelence costs commonly run approximately $1,500–$2,200 per month.
- Through AffordMyPrescriptions, qualifying patients can access Intelence for a flat $69.95 per month.
- Other NNRTIs: efavirenz (Sustiva — generic), rilpivirine (Edurant, and in single-tablet regimens Complera generic, Odefsey brand, Cabenuva long-acting IM), doravirine (Pifeltro, and Delstrigo brand — active against some resistant HIV). Standard first-line HIV regimens use INSTIs (integrase strand transfer inhibitors — dolutegravir generic, bictegravir in Biktarvy — most-prescribed HIV single tablet). Intelence is specifically for NNRTI-resistant HIV in treatment-experienced patients. HIV specialist prescribing with resistance testing.
What is Intelence Prescription Assistance Program?
The Intelence Patient Assistance Program is a manufacturer-sponsored initiative that helps eligible patients access Intelence (used in NNRTI-resistant treatment-experienced HIV) at little or no cost when they meet specific income, insurance, and clinical criteria. The program is free to apply for, but enrollment involves detailed applications, HIV specialist coordination, resistance testing documentation, and ongoing renewal.
At AffordMyPrescriptions, our Patient Advocates handle the entire Intelence PAP enrollment for a flat $69.95 per month — application, prescriber coordination, follow-up, refill management, and annual re-certification — so you never face a gap in your Intelence HIV therapy.
AffordMyPrescriptions eliminates that burden. For a flat $69.95 per month, our Patient Advocates handle every step of your Intelence enrollment — so you never face a gap in your treatment-experienced HIV therapy.
Pharmacy Price Comparison
- Without assistance, Intelence costs thousands of dollars per month at specialty pharmacies. A Patient Assistance Program can offset costs if you qualify:
| PHARMACY | PRICE (30-DAY) WITH BEST COUPONS | YOU SAVE W/ US |
|---|---|---|
| Ryan White HIV/AIDS Program | programs | State ADAP funding |
| Walgreens Specialty | ~$2,100/mo | Save substantially |
| CVS Specialty | ~$2,200/mo | Save substantially |
| Walmart Specialty | ~$1,700/mo | Save substantially |
| Specialty pharmacy | ~$1,500/mo | Save substantially |
| Generic efavirenz (alt NNRTI) | ~$40/mo | Generic alt (unless resistant) |
*Retail prices are estimates based on public data and vary by pharmacy. Coupon prices from GoodRx and SingleCare as of April 2026. AffordMyPrescriptions Advocacy Service bypasses pharmacy pricing entirely by using the manufacturer’s assistance program to secure your Intelence — independent of dosage or retail price.
Our Pricing:
$69.95 Per month
1 Medications
$79.95 Per Month
2 Medications
$89.95 Per Month
3 Medications
$99.95 Per Month
4+ Medications
Why choose us For Your Intelence Prescription Program?
The Intelence Patient Assistance Program is free to apply. Our $69.95 per month covers full advocacy. Ryan White HIV/AIDS Program and state AIDS Drug Assistance Programs (ADAP) fund HIV treatment for uninsured/underinsured. For treatment-experienced patients with NNRTI resistance, Intelence is one of few active NNRTI options.
Enroll
Complete a simple eligibility form so our team can determine if you may qualify for Intelence assistance.
We Advocate
Our specialists gather documentation, complete applications, and coordinate with your prescriber and the assistance program.
Receive Medication
Once approved, your Intelence is delivered through the assistance program while we manage refills and annual renewals.
Discount Coupons vs. Patient Assistance Programs
Many patients try discount cards first. Here’s why the Patient Assistance Program through AffordMyPrescriptions is the better long-term solution for Intelence:
Limitations of Coupons
Prices fluctuate — savings aren’t guaranteed month-to-month
Copay accumulators may prevent savings from counting toward your deductible
Coupon cards expire and require constant renewal
Still $1,500–$2,200 per month even with the best discount
Cannot be used with Medicare, Medicaid, or government insurance
Advantages of PAP Through Us
Fixed $69.95/month — never changes regardless of retail price
- No expiration — continuous access as long as you qualify
Medication supplied directly through the assistance program
We manage all paperwork, refills, and annual renewals
Medicare Part D patients accepted
If denied, we explore alternative savings paths on your behalf
DO YOU QUALIFY?
Eligibility is generally determined by annual household income and insurance status. Most programs follow guidelines that include limits of up to $40,000 for individuals, $60,000 for couples, and $100,000 for larger families. Because requirements vary by program and household, we encourage you to contact AffordMyPrescriptions directly so we can review your specific situation and determine if you qualify for Intelence assistance.
- You Are A U.S. Citizen Or Legal Resident
- You Have A Valid Intelence Prescription From A Licensed U.S. Healthcare Provider
- You Are Uninsured, Underinsured, Or A Medicare Part D Beneficiary
- You Have Recently Experienced A Change In Financial Circumstances That Affects Your Ability To Pay
Understanding Intelence:
Intelence is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with retained activity against many NNRTI-resistant HIV strains. It has a different resistance profile than first-generation NNRTIs (efavirenz, nevirapine) — a key drug for treatment-experienced patients with NNRTI resistance.
How It Works:
HIV requires the reverse transcriptase enzyme to convert viral RNA to DNA. NNRTIs bind reverse transcriptase at an allosteric site — non-competitive inhibition of viral replication. First-generation NNRTIs (efavirenz, nevirapine) develop resistance via single point mutations that historically eliminate activity of the entire NNRTI class. Etravirine is a diarylpyrimidine NNRTI designed for flexibility — retaining activity against HIV with common first-generation NNRTI resistance mutations (K103N and others). Combined with resistance testing to select active drugs, it provides an NNRTI-based option for treatment-experienced patients. Doravirine (Pifeltro) is a newer NNRTI with a similar concept.
Form and Use:
Intelence tablets 25 mg, 100 mg, 200 mg. Adult dose: 200 mg twice daily with meals. Pediatric weight-based dosing. Take with food (increases absorption significantly). Must be part of a combination antiretroviral regimen (2+ other active drugs). HIV specialist prescribing with resistance testing.
Generic Availability:
No generic Intelence. Other NNRTIs: efavirenz (Sustiva — generic; first-generation, single-daily dosing; CNS side effects; component of generic Atripla combo), rilpivirine (Edurant — brand; and in single-tablet regimens Complera, Odefsey, Cabenuva LA), doravirine (Pifeltro — brand, similar concept to etravirine; Delstrigo combo), nevirapine (Viramune — generic; older NNRTI with hepatotoxicity concerns). Standard first-line HIV regimens use INSTIs (integrase inhibitors — dolutegravir generic, bictegravir in Biktarvy — most-prescribed HIV single-tablet regimen — brand, cabotegravir long-acting in Cabenuva/Vocabria, raltegravir generic). Protease inhibitors (darunavir generic, atazanavir generic) for specific scenarios. Full HIV regimen optimization requires resistance testing and an HIV specialist. Ryan White HIV/AIDS Program funds treatment; state ADAP; HIV Medicine Association resources.
Warnings:
Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS — rare but serious; discontinue for severe rash), hypersensitivity reactions, immune reconstitution inflammatory syndrome (IRIS), hepatic effects (monitor LFTs). Other: rash (very common — usually mild), nausea, diarrhea, peripheral neuropathy. Take with food. Drug interactions are complex — CYP3A4 substrate and inducer, CYP2C9/2C19 inhibitor — with many interactions with other antiretrovirals and non-HIV medications (rifampin, statins, warfarin, azoles, anticonvulsants). HIV specialist and pharmacist review of the entire regimen is essential.
FAQ (Frequently Asked Questions)
How much does Intelence cost without insurance?
$1,500–$2,200 per month at specialty pharmacies. Generic efavirenz (a first-generation NNRTI — a cheap alternative but not effective against NNRTI-resistant HIV) costs ~$30–$40 per month.
How is Intelence different from other NNRTIs?
Intelence (etravirine) is a second-generation NNRTI with retained activity against many first-generation NNRTI-resistant HIV strains (including the K103N mutation that eliminates efavirenz activity) — making it a key option for treatment-experienced patients with NNRTI resistance. Doravirine (Pifeltro) is a newer similar-concept NNRTI with a slightly different resistance profile and once-daily dosing.
Can I take Intelence for first-line HIV treatment?
Standard first-line HIV regimens today use INSTIs (integrase inhibitors — Biktarvy, Dovato, Triumeq, dolutegravir generic-based combos) rather than NNRTIs. Intelence is specifically FDA-approved for treatment-experienced HIV with NNRTI resistance. Discuss with your HIV specialist for regimen selection based on resistance testing.
Why must Intelence be taken with food?
Food significantly increases etravirine absorption — taking it without food reduces drug levels by ~50%, risking treatment failure and resistance. Take twice daily with meals. Consistent food intake is important for reliable drug levels.
What are common Intelence side effects?
Rash is very common early in treatment — usually mild, but discontinue for severe rash (SJS/TEN or DRESS risk). Nausea, diarrhea, peripheral neuropathy. Serious skin reactions are rare but require immediate discontinuation.
Take Control of Your Medication Costs
HIV therapy must not lapse — resistance and viral rebound risk. Our advocacy team is ready — $69.95 per month, or free if we cannot help.
Submit Enrollment Form
Start free by filling out a simple online form.
Receive Welcome Call
Our specialist will contact you for a quick welcome call.
We Manage The Process
Our team handles everything, so you can focus on your health.